Online Registration

ISO 9001:2015

INTERNATIONAL JOURNAL OF GLOBAL RESEARCH INNOVATIONS & TECHNOLOGY (IJGRIT) [ Vol. 4 | No. 3 | July - September, 2026 ]

Simultaneously Synergistic Effects of Moringa Oleifera Aqueous Leaf Extract on Metabolic Syndrome Parameters

Brijesh Kumar Prajapati & Dr. H. C. Kataria

Metabolic syndrome is a condition with multiple components such as central obesity, insulin resistance, hyperglycaemia, dyslipidaemia and high blood pressure and it all contributes to the risk of developing type 2 diabetes and cardiovascular disease. These abnormalities are closely linked to each other, and treatment aimed at several metabolic pathways is of great interest. Moringa oleifera Lam. is a tree that has been scientifically studied due to its leaves containing flavonoids, phenolic acids and other antioxidant compounds. The aqueous leaf extract is of special significance since it offers a simple and readily available approach to obtaining a number of water-soluble bioactive components. The possible synergistic effect of M. oleifera aqueous leaf extract in the significant metabolic syndrome parameters is reviewed here. Preliminary research indicates that it has positive effects on glucose metabolism, insulin sensitivity, lipid metabolism, oxidative stress, inflammation, and visceral adiposity. The effects of these compounds can occur through synergistic mechanisms such as insulin signalling and glucose and lipid metabolism, AMPK activity, and antioxidant defence. There is limited human evidence, though some have found to improve fasting glucose and HbA1c. In general, M. oleifera has been found to have good multi-target metabolic activity, however more standardized and well-designed clinical trials are needed to determine its therapeutic efficacy and confirm its true synergistic effects.

Prajapati, B. & Kataria, H. (2026). Simultaneously Synergistic Effects of Moringa Oleifera Aqueous Leaf Extract on Metabolic Syndrome Parameters. International Journal of Global Research Innovations & Technology, 04(03), 248–257. https://doi.org/10.62823/ijgrit/04.03.9598
  1. Afiaenyi, I. C., Ngwu, E. K., Okafor, A. M., & Ayogu, R. N. (2025). Effects of Moringa oleifera leaves on the blood glucose, blood pressure, and lipid profile of type 2 diabetic subjects: A parallel group randomized clinical trial of efficacy. Nutrition and Health, 31(1), 281–291. https://doi.org/10.1177/02601060231176873.
  2. Adarthaiya, S., & Sehgal, A. (2023). Moringa oleifera Lam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies. Phytotherapy Research. https://doi.org/10.1002/ptr.8079.
  3. Crișan, D., et al. (2025). Effects of Moringa oleifera Lam. supplementation on cardiometabolic outcomes: A meta-analysis of randomized controlled trials with GRADE assessment. Nutrients.
  4. Fahey, J. W. (2005). Moringa oleifera: A review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1. Trees for Life Journal, 1, 5.
  5. Jaiswal, D., Rai, P. K., Kumar, A., Mehta, S., & Watal, G. (2009). Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. Journal of Ethnopharmacology, 123(3), 392–396. https://doi.org/10.1016/j.jep.2009.03.036.
  6. Vergara-Jimenez, M., Almatrafi, M. M., & Fernandez, M. L. (2017). Bioactive components in Moringa oleifera leaves protect against chronic disease. Antioxidants, 6(4), 91.
  7. Stohs, S. J., & Hartman, M. J. (2015). Review of the safety and efficacy of Moringa oleifera. Phytotherapy Research, 29(6), 796–804. https://doi.org/10.1002/ptr.5325.
  8. Waterman, C., Rojas-Silva, P., Tumer, T. B., Kuhn, P., Richard, A. J., Wicks, S., Stephens, J. M., Wang, X., & Raskin, I. (2015). Isothiocyanate-rich Moringa oleifera extracts and their potential for diabetes management. Phytochemistry.
  9. Mbikay, M. (2012). Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: A review. Frontiers in Pharmacology, 3, 24.
  10. Abd Eldaim, M. A., Diki, B. M., & Abd El-Rahman, H. G. (2020). Moringa oleifera Lam. leaf extracts reverse metabolic syndrome in Sprague Dawley rats fed high-fructose high-fat diet for 60-days. Journal of Ethnopharmacology.
  11. Arnarson, A., et al. (2022). Moringa oleifera leaf supplementation as a glycemic control strategy in subjects with prediabetes. Nutrients, 14(1), 57. https://doi.org/10.3390/nu14010057.
  12. Acuram, L. K., & Chichioco Hernandez, C. L. (2019). Anti-hypertensive effect of Moringa oleifera Lam. Cogent Biology, 5(1), 1596526.
  13. Leone, A., Spada, A., Battezzati, A., Schiraldi, A., Aristil, J., & Bertoli, S. (2015). Cultivation, genetic, ethnopharmacology, phytochemistry and pharmacology of Moringa oleifera leaves: An overview. International Journal of Molecular Sciences, 16, 12791–12835.
  14. Tiloke, C., Phulukdaree, A., & Chuturgoon, A. A. (2018). The antidiabetic effects of Moringa oleifera extracts. Journal of Diabetes Research.
  15. Yassa, H. D., & Tohamy, A. F. (2014). Extract of Moringa oleifera leaves ameliorates streptozotocin-induced diabetes mellitus in adult rats. Acta Histochemica, 116(5), 844–854.
  16. Lin, M., et al. (2021). Moringa oleifera: A systematic review of its botany, traditional uses, phytochemistry, pharmacology and toxicity. Journal of Pharmacy and Pharmacology. https://doi.org/10.1093/jpp/rgab131.
  17. Abdull Razis, A. F., Ibrahim, M. D., & Kntayya, S. B. (2014). Health benefits of Moringa oleifera. Asian Pacific Journal of Cancer Prevention, 15, 8571–8576.
  18. Stohs, S. J., Hartman, M. J., & others. (2019). Moringa oleifera as a functional food and medicinal plant: Review of biological activities and safety considerations.
  19. Saleem, A., Saleem, M., & Akhtar, M. F. (2020). Antioxidant, anti-inflammatory and anti-diabetic potential of Moringa oleifera. Current Pharmaceutical Biotechnology.
  20. International Diabetes Federation Task Force on Epidemiology and Prevention, NHLBI, AHA, World Heart Federation, IAS, & IASO. (2009). Harmonizing the metabolic syndrome: A joint interim statement. Circulation, 120, 1640–1645.

https://doi.org/10.1161/CIRCULATIONAHA.109.192644.

  1. Zhan, J., et al. (2026). Moringa oleifera leaves water extract as a novel therapeutic agent for hyperlipidemia prevention: Integrated analysis of bioactive components and metabolic regulatory pathways. Food Research International.
  2. Mehrzad Samarin, M., et al. (2026). The effect of Moringa oleifera on body weight and blood pressure: A systematic review and meta-analysis of randomized controlled trials. Food Science & Nutrition, 14(5), e71899.

DOI:

Article DOI: 10.62823/ijgrit/04.03.9598

DOI URL: https://doi.org/10.62823/ijgrit/04.03.9598

Download Full Paper:

Download