Gastric ulcers and the associated disorders caused by oxidative stress are a significant concern to global health, and effective and safer therapeutic alternatives based on plants must be investigated. The purpose of this research is to compare the phytochemical composition and pharmacological potential of Combretum indicum Linn and Thevetia peruviana, in terms of antioxidant and antiulcer activities. The study was done by standard experimental techniques (plant materials were extracted by aqueous and ethanolic methods), and then, qualitative phytochemical screening was done. The DPPH free radical scavenging assay was used to analyze the antioxidant activity and the pylorus ligation induced ulcer models in experimental animals were used to analyze antiulcer activity. The findings indicated that ethanolic extracts had a much higher extractions yield and phytochemical content than aqueous extracts. Quantitative analysis revealed that ethanol extracts were more antioxidants, with lower IC50, suggesting greater free radical scavenging capacity. Ethanol extracts demonstrated comparatively greater effects in other antiulcer investigations, where the treated groups displayed low levels of stomach acidity, ulcer index, and mucosal protection of the gastrointestinal system. In conclusion, the study demonstrates that Thevetia peruviana and Combretum indicum both have significant antioxidant and antiulcer properties, however ethanolic extracts are more potent. These findings suggest that they may be utilised as natural medicinal agents, and more research is necessary to convert them into medications and apply them in clinical settings.
Bhadouria, A. (2026). Phytochemical Study & Pharmacological Evaluation with Comparison of Antioxidant and Antiulcer Activity of Combtetum Indicum Linn and Thevetia Peruviana (Pers.). International Journal of Education, Modern Management, Applied Science & Social Science, 08(01(II)), 155–167. https://doi.org/10.62823/IJEMMASSS/8.1(II).8764
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