Women must be treated with the appropriate respect, dignity, justice, and equality; only then will they be empowered in the fullest sense of the word. Employees in the hybrid work paradigm have unprecedented opportunities to improve their family life, career aspirations, and general well-being. Women's workplace empowerment in India and around the world has been greatly aided by hybrid working shifts. This is a result of the flexible work culture created by hybrid working, which has become more prevalent since the epidemic and is drawing more women to the workplace.  This study explores the widely used hybrid work paradigm, which is receiving a lot of attention in the IT and ITeS sectors. It focuses on female employees and seeks to analyze how they see office, remote, and hybrid work modes. Hybrid working methods have been a revolutionary advancement in the organization of contemporary labor in recent years. However, the majority of previous study has mostly focused on the financial benefits of hybrid work for businesses, frequently ignoring its wider societal effects, especially those related to women's employment. Additionally, not enough research has been done on the wider ramifications of hybrid labor in various cultural and social situations. The simultaneous pressures of career and household responsibilities have made occupational stress a major worry in today's workplace, with women employees suffering disproportionately. Employee stress-coping tactics have an impact on an employee's performance due to a number of reasons, including peer interactions, job satisfaction, motivation, occupational stress, and remote working issues. The results of the multiple mediation study show that the mediator variables—occupational stress and job satisfaction—have no statistically significant impact on performance when working remotely. Workload, job insecurity, a poor work environment, personal issues, and a lack of structure are the top five causes of occupational stress for female IT workers who work from home, according to the exploratory factor analysis. The study's multiple regression analysis shows that there is an inverse and adversely significant association between the five components of occupational stress and mental health. We will talk about this in this paper. Occupational Stress, Women's Empowerment, and Hybrid Work Culture: A Cultural Sustainability Viewpoint in the IT Sector.