The Shekhawati region in Rajasthan, India, is known for its arid climate and scarce water resources, especially groundwater. Groundwater is the main source of water for drinking, irrigation, and industrial purposes in this region. However, the quality of groundwater has been compromised due to several anthropogenic and natural factors. This study aims to assess the physicochemical parameters of groundwater in the Shekhawati region, focusing on its suitability for drinking, agriculture, and industrial use. The study evaluates parameters such as pH, electrical conductivity (EC), total dissolved solids (TDS), alkalinity, hardness, chloride, nitrate, fluoride, and heavy metals. The results are compared with the drinking water standards prescribed by the Bureau of Indian Standards (BIS) and the World Health Organization (WHO) to understand the potential health implications for the local population. Additionally, the research explores the impacts of land use, agriculture practices, and mining activities on groundwater quality.