Beneath the smooth trail of macroeconomic aggregates there is a incredibly active microeconomic world of start-ups that play an important role in innovation and in the evolution of markets. This paper attempts to explore the opportunities and threats of Start-up India, a campaign by Modi Government, on the parameters of Hofstede's model of cultural dimensions. While Uncertainty avoidance, Long Term Orientation, and Indulgence are in favour of Indian Entrepreneurship ecosystem, Power Distance, Masculinity, and Individualism are threats to its smooth survival.