Organic synthesis utilizes Schiff base reactions to create carbon-nitrogen bonds, with Schiff bases serving as bi, tri, or tetra dentate ligands that can form highly stable complexes with transition metals. In various enzymatic reactions, Schiff bases derived from semicarbazones play a crucial role as intermediates, facilitating the interaction between an enzyme and either an amino or carbonyl group of the substrate. One of the key catalytic mechanisms in biochemical processes involves the condensation of a primary amine, typically found in a lysine residue of the enzyme, with a substrate's carbonyl group to produce an imine or Schiff base. Many of these compounds exhibit biological activities, including antibacterial, antifungal, and antitumor properties. This paper summarizes the synthesis and spectroscopic analysis of 2-acetyl-1-naphtholsemicarbazone (2-Ac-1-naphtholSc) Schiff base and its Cu(II) complex.

Keywords: Schiff Bases, Transition Metal Complexes, Spectroscopic Analysis and Biological Activity.

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