Stroke is a major cause of morbidity and mortality worldwide. Despite advances in stroke prevention and treatment, there is a subset of patients who experience recurrent strokes and exhibit poor responses to antiplatelet drugs. This research paper investigates the higher risk of recurrent strokes and poor drug response in patients with specific genetic profiles, particularly the presence of loss-of-function alleles of CYP2C19 and P2Y12. The study employs a comprehensive literature review and a robust research methodology to elucidate the genetic factors contributing to these clinical phenomena. Our findings highlight the importance of genetic profiling in personalized medicine for stroke prevention and treatment.

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Keywords: Stroke, Recurrent Strokes, Drug Response, Genetic Profiles, CYP2C19, P2Y12.