Medicinal Plants have been a vigorous source of Phytomedicines. Endophytes are microorganisms that live in host tissues and establish a mutual association. These microbes are excellent source of bioactive compounds. Plants infected with endophytes are generally healthier than endophytes free ones. These endophytes are the potent source of secondary metabolites similar to the plant tissue on which these endophytes are grown. These chemical metabolites of plants can be derived from any part of plant like stem, bark, leaves, flowers, roots, fruits, seeds etc. Synthesis of these compounds increases many folds in association with endophytes. These microbial endophytes reside in host plants without causing any symptoms of infection so they are gaining attention of researchers for research related to these endophytes in many aspects such as in agriculture, medicines, environmental studies etc.  In the recent development of research, the medicinally important genus Tribulus terrestrishas a fewer extent of microbial endophytes specificity. A very limited study has been accessible on bioactive compounds isolated from endophytes and their role in health related benefits. Therefore, this review article presents an assessment and will prominently contribute a knowledge about the endophytes reside in the different genus of family Zygophyllaceae specially Tribulus terrestris as a source of bioactive and chemically novel compounds along with various biochemical activities.

Keywords: Microbial Endophytes, Symbiotic, Bioactive Compounds, Agriculture, Exploration, Zygophyllaceae, Phytomedicines.