Silver charged water; in which silver is present in nanoparticulate form is used as an Ayurvedic medication from ancient time. Study was done to evaluate the changes in the physiochemical parameters in Silver charged water and biochemical changes after 5 Gy whole body irradiation and its modulation by supplementation of silver charged water on male Swiss albino mice brain. For this, healthy mice from an inbred colony were divided into four groups: (i) Control-vehicle treated  (ii) Silver charged water treated- mice in this group were orally supplemented with silver charged adlibitum for one month; (iii) Irradiated (iv) Silver charged water + irradiated- mice in this group were orally supplemented with Silver charged water for one month prior to irradiation. Marked radiation induced changes in the amount of whole brain lipid peroxidation (LPO), Glutathione (GSH) are significantly (p < 0.001) ameliorated specially by supplementation of silver charged water prior to irradiation. The results of present study showed that prior supplementation of silver charged water has radioprotective potential as well as neuroprotective properties against the radiation.

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Keywords: Whole Brain, Silver Charged Water, Oxidative Stress, Lipid Peroxidation, Glutathione, Silver Nanoparticles.