Antibiotics are the most successful family of drugs as yet developed for improving animal and human health. Due to the increasing antibiotic resistance to of many bacteria, plant extracts are of new interest as antiseptics and anti-microbial agents in medicine. Aloe vera is a medicinal plant part of the family Liliaceae. This study investigated the phytoconstituents and anti-microbial activity of Aloe vera root extract. Phytochemical screening confirmed that the methanolic section showed the best possible number of phytochemicals compared with solvents like Acetone and chloroform. Extracting of roots in chloroform exhibits the presence of rich phytochemicals compared with Acetone and methanol. The anti-microbial activity of Aloe vera root extract was examined using the disc diffusion method in 3 human pathogens like Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and fungi like Aspergillus Niger and Penicillium chrysogenum. The extract has inhibitory effect against both bacteria and fungus. This research study would be helpful for the development of new medications and formulations.

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Keywords: Anti-Microbial Activity, Microorganism, Aloe Vera Root.