At present scenario life is full of deadlines, hassles, demands and frustrations. For many people, stress is so common place that it has become a part of their life. Stress isn’t always bad. In small doses, it can help you perform under pressure and motivate you to do your best but your mind and body pay the price by constantly running in emergency mode. You can protect yourself by recognizing the signs and symptoms of stress and taking steps to reduce its harmful effects. Define stress as a "relationship between the person and the environment that is appraised by the person as taxing or exceeding his or her resources and endangering his or her wellbeing." Stress is a common human experience frequently blamed for much of the ill health individuals’ experience. Much focus is been given to the effect of stress on health and wellness. Research demonstrates a strong relationship between psychological stress and health. This paper shows that how stress can be harmful for the human body that an individual can be move onto suicide. Stress effects a human mind by which the power of thinking totally get changed, firstly stress change the human psychology and afterwards it effects the human attitude, motivation, personality, behavior, inspiration, positive thinking, decision making etc. Here not only the stress has been described but also mention that how you can check your stress level and how you can manage it.