This study was conducted in Debre Berhan, located 125 k.m distances from Addis Ababa capital of Ethiopia. Debre Berhan  is a city in central Ethiopia and located in Amhara region. This case study focuses on the survival analysis of HIV/AIDS patients. HIV refers to human immunodeficiency virus; it is a collection of virus those most likely mutated decades ago from a virus that infected chimpanzees to a virus that infects humans. It began to spread beyond the African continent in the late 1970s and is now endemic worldwide. HIV infection leads to low levels of CD4+ T cells that in turn make the body susceptible to opportunistic infection. The introduction of ART in 1996 was a turning point for thousands of people with sophisticated health care. Retrospective fife years HIV/AIDS Disease cohort study was conducted in patients, who were undergoing Antiretroviral Therapy in the ART clinic of Debre Berhan Referral Hospital, Debre Berhan, Ethiopia, during the period of January 2013 up to January 2018 were followed up through the ART routine registered recorded up to January 2018 taken from patients chart. Survival data was recorded. The data were collected at random by using simple random sample form the patient's data card .Further from this study, we observed the following results. Survival of patient is affected by sex that means being a male’s decrease survival time than being a female. In the base line regimen class taking the first has high survival time than taking the second class that means when regimen is change from first to next time of survival is decrease.  Survival is affected by functional status. WHO clinical stages, that is stage1 has high survival time than others, opportunistic infection and marital status.

Keywords: Survival Analysis, HIV/AIDS, Kaplan-Meier Plots, ART.